研究明确区分了两种细胞的作用机制: 干细胞依靠分化替代受损细胞，而基质细胞则通过归巢和分泌重塑微环境。这一突破性发现彻底纠正了长期以来对MSCs安全性与有效性的误解，确立了间充质基质细胞的身份鉴定标准，为个性化治疗开辟了新途径。

综上所述，该研究表明细胞外囊泡来源的 tRF-02514 通过调节多种通路对帕金森病产生影响。tRF-02514 可促进炎症因子释放，诱导小胶质细胞焦亡，加速神经元丢失；而抑制 tRF-02514 则能有效减轻这些有害影响，保护神经元，促进自噬，延缓 PD 进展 。这一研究为深入理解 PD 的发病机制提供了新的视角，也为 PD 的治疗提供了潜在的新靶点。未来，针对 tRF-02514 ...

Kanazawa University and colleagues have developed a promising new approach to cancer treatment. By using tiny, naturally ...

Age-related macular degeneration (AMD), the leading cause of adult blindness, affects nearly half of Oklahomans over age 80.

Kanazawa University and colleagues have developed a promising new approach to cancer treatment. By using tiny, naturally ...

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Animal experiments also showed the ion channel influences the cargo, meaning the protein is important not just to the structure of extracellular vesicles (EVs), but also their function.

Kanazawa University, demonstrate a novel approach for nanoscopic profiling of small extracellular vesicles (sEVs) using ...

High-speed atomic force m (HS-AFM) reveals nanoscale differences in small extracellular vesicles (sEVs), improving biomarker ...