This important study shows that nutrient stress emanating from the microenvironment induces metabolic vulnerabilities in pancreatic ductal adenocarcinoma (PDAC). Using a combination of cell-based and ...

These observations led to the discovery of acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS), the two key enzymes of fatty acid synthesis. His laboratory was the first to identify these ...

Obesity and related metabolic disorders, such as hyperlipidemia and non-alcoholic fatty liver disease, have become ...

coli-based synthesis of fatty acids via simulations ... While the overexpression of ACC increases fatty acid yield, excessive ...

The human body uses three types of molecules to yield the necessary energy to drive ATP synthesis ... complete oxidation of one molecule of fatty acid, and almost forty ATP molecules result ...