All studies but one required documented FGFR abnormalities for eligibility. Adverse events (AEs) were graded from 1 to 5 (G1-5) on the basis of the Common Terminology Criteria for Adverse Events v5.0.

and fibroblast growth factor receptor 1 (FGFR1), are validated drug targets for therapeutic intervention, others remain challenging and are not yet amenable to modulation by anticancer agents.

In mammals, the fibroblast growth factor (FGF)-FGF receptor (FGFR) interactions control many physiological processes during development and life. Impaired FGFR signaling has been associated with ...

A study demonstrates the role of the Galectin-1 protein in the nucleus of the cells surrounding the tumor -- fibroblasts -- contributing to their activation. Activated fibroblasts promote tumor growth ...