The main role of the telomere bouquet was thought to be the promotion of recombination, but Tomita and Cooper now report in Cell that, in fission yeast, the telomere bouquet has a crucial role in ...

The Protection of Telomeres 1 (Pot1) protein is a central component of the shelterin complex at telomerase and is conserved from fission yeast to humans. Pot1 binds directly to the 3’ single-stranded ...

These experiments will be invaluable in deciphering the broad biochemical functions of both the tRPA complex and telomere proteins in general. Our lab is engaged in understanding the structures and ...

Here, Artandi and DePinho discuss how studies in mice have uncovered a complex interplay between the ARF-p53 pathway, genomic instability due to telomere dysfunction, and the suppression or ...

In addition, it binds to the promoter sequences (dark blue) of specific target genes including mitochondrial fission process 1, MTFP1. In the absence of ZBTB48 (right panel) telomeres become ...