Over the past fifteen years, great strides have been made to understand how heterotrimeric G proteins control their ... allosteric machines with multiple signaling outputs. You have full access ...

The signal transduction cascade begins when adenylyl cyclase, a membrane- bound enzyme, becomes activated by G-protein molecules associated with the adrenergic receptor. Adenylyl cyclase creates ...

Cysteinyl leukotrienes (CysLTs) are potent bronchoconstrictors, playing pivotal roles in inflammatory diseases. These lipid mediators exert their effects by activating two G protein-coupled receptors, ...

They have identified a crucial protein, G protein-coupled receptor ... leading to increased AT1R signaling, which triggers a ...