Over the past fifteen years, great strides have been made to understand how heterotrimeric G proteins control their ... allosteric machines with multiple signaling outputs. You have full access ...

Scaffolding proteins physically link pathway components, thereby forming signalling modules that markedly affect spatiotemporal control of signalling and specificity of inputs and outputs.

They have identified a crucial protein, G protein-coupled receptor ... leading to increased AT1R signaling, which triggers a ...

Cysteinyl leukotrienes (CysLTs) are potent bronchoconstrictors, playing pivotal roles in inflammatory diseases. These lipid mediators exert their effects by activating two G protein-coupled receptors, ...