One of the most powerful ways of studying the function of a protein is to specifically ... as mutant Ras proteins that lack GTPase activity, which normally turns Ras off, were found in many ...

In 2000, Zhang & Clarke used a strategy with artificial beads to prove the direct function of Ran GTPase in NE assembly. The artificial beads are made of solid sepharose, and thus have the ...

Loss-of-function variants in ITSN1 confer high risk ... The role of ITSN1, Intersectin-1, is to activate CDC42, a small Rho GTPase involved in the growth and maintenance of dopaminergic neurons ...