How does Ran GTPase control both protein import during interphase and spindle attachment to the chromosomes during M-phase? It all has to do with its concentration gradient in the cell.

"Since these GTPases switch between 'on' and 'off' states ... openly in the hopes that others will use them to drug their GTPase of interest, whether it's a Rab GTPase, which is implicated ...

and that assembly of this wound actin cable is dependent on the small GTPase switch, Rho. We subsequently established the Drosophila embryo as a model to image the wound re-epithelialisation process ...