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缺氧耐受性决定猪和小鼠对钩吻素乙神经毒性差异的研究成果揭示
猪似乎对钩吻及其生物碱具有显著的抵抗力 ... 其中海马体在钩吻素乙毒性过程中起关键作用。钩吻素乙的毒性与 GABA 和谷氨酸能通路有关,它通过调节 GABA A R 的功能诱导呼吸抑制,导致缺氧,进而引发 NMDAR 过度兴奋,造成神经毒性。此外,钩吻素乙还会引起 ...
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