The γ-secretase complex is an aspartic intramembrane protease comprised of presenilin as a catalytic subunit, nicastrin, anterior pharynx-defective 1 and presenilin enhancer 2. Significant ...

Gamma-secretase acts like a pair of molecular scissors ... resulting in a ‘stuck’ or stalled complex. According to the ...

Research suggests that mutations in the gamma-secretase complex, which plays a key role in Notch signaling, often increase the risk of HS. Notch signaling has several important functions ...