Translation of human pluripotent stem cells into cell therapies ... remarkably similar in phenotype to spontaneously occurring germ cell teratomas. It is possible that we can use the extensive ...

Two weeks after a human egg is fertilized, primordial germ cells (PGCs), which develop into sperm and eggs, are formed. In six to 10 weeks after fertilization, PGCs differentiate into pro ...

A potential undesirable side effect of somatic gene therapy is that, during gene delivery, foreign DNA reaches the gonadal tissue and inserts into the germ cell genome, with the risk of ...

A toothpick and a bit of chance shaped David Page’s career, which he has dedicated to understanding the mammalian Y chromosome and fetal germ cell development. A series of rodent experiments showed ...

Where the law takes issue however, are any changes to “germ line” cells — those that could pass on edits to a future human. Namely, eggs or sperm. Recently, Canadian researchers, working ...

resilience depends on a functional piRNA pathway to protect germ cell genomes decades after puberty, which is the point in humans when the Piwi pathway is activated, as well as the expression of ...

However, IVG research also raises ethical questions, including the implications of creating children if the generation of human reproductive cells becomes successful in the future. As we carry out our ...