Next, the investigators queried the identity of the pulled-down DNA by PCR, using primer pairs to amplify short sequences spanning the entire β-globin gene region. The DNA that was pulled down by ...

Thalassemia is classified into two main types based on which part of the haemoglobin molecule is affected: Alpha Thalassemia Cause: Mutations in the genes responsible for producing alpha-globin ...

While thalassemia is caused by a defect in the beta-globin gene, controlling the production of the beta-globin chains of haemoglobin, sickle cell disease is caused by a defect in haemoglobin ...