Hepatocellular carcinoma (HCC), the third leading cause of cancer-related deaths worldwide, remains one of the most ...

Chronic and persistent HBV infection is associated with weak and functionally impaired immune response. The persistent exposure to viral antigens leads to virus-specific CD4 and CD8 cell ...

To clear acute infection, the immune system needs to mount a strong HBV-specific CD8+ and CD4+ T cell responses, but in chronic HBV, T cell responses are dysfunctional 5. Scientists are currently ...

CD8-positive T cells are a critical subpopulation of MHC class I-restricted T cell and are mediators of adaptive immunity. They include cytotoxic T cells, which are important for killing cancerous ...