Nature9mon
Targeting the glycans of glycoproteins: a novel paradigm for antiviral therapy
When HIV is exposed to CBAs, virus escape eventually occurs predominantly by deleting its glycans on the viral envelope glycoprotein gp120. It has been shown that such mutant virus strains have an ...
Small protein plays big role in chronic HIV infection
The study shows that intact HIV and its viral envelope protein gp120 each cause macrophages, a type of white blood cell, to ...
Medscape5d
Role of CXCR4 in HIV Infection and its Potential as a Therapeutic Target
Determinants of HIV cell tropism & chemokine receptor usage The V3 loop of HIV-1 gp120 is a primary determinant of cell tropism and chemokine receptor usage, whereas the V1/V2 region is involved ...
News-Medical.Net on MSN8d
Gilead’s capsid revolution meets our capsid solutions: Sino Biological – Engineering the tools to outsmart HIV
Gilead Sciences announced a significant milestone: the U.S. FDA accepted their New Drug Applications (NDAs) for lenacapavir ...
Nature10y
Bioinformatics prediction of HIV coreceptor usage
Preventing HIV cell entry There is no cure for AIDS ... viral strains carrying different maraviroc resistance–conferring mutations within gp120 have been observed both in cell culture ...