In this article we give an overview of RNA-based HPV diagnostics and the role of E6/E7 mRNA detection as a predictive marker for the development of cervical carcinoma. HPV E6/E7 mRNA testing for ...

虽然我们早已知道 HR-HPV 的 E6 和 E7 这两种癌蛋白在致癌过程中 “兴风作浪”，可它们具体是如何 “作恶” 的，还有哪些潜在的 “帮凶”，一直是科学界亟待解开的谜题。而且，目前针对 HPV + 癌的治疗手段有限，急需开辟新的治疗路径。 在这样的背景下 ...

Gen-Probe is currently developing the APTIMA HPV Assay, targeting E6/E7 mRNA from 14 carcinogenic HPV genotypes. A prototype of this assay was evaluated recently in 536 women with histological ...

为探究 HPV31 和 HPV35 的遗传变异及致癌性，绍兴大学医学院等单位的研究人员开展相关研究，分析其 E6/E7 基因变异、构建进化树等。结果揭示多种变异体特征。该研究为 HPV 防治和疫苗研发提供关键依据，值得一读。 绍兴大学医学院（School of Medicine, Shaoxing ...

Single-cell analysis revealed the molecular triggers that drive stem cells to become cancerous, which may help inform ...

Enzo’s innovations are changing the story of HPV. The FLOWSCRIPT® Assay employs a novel, flow cytometry-based, in situ hybridization technique, utilizing a cocktail of probes specific to multiple ...

The E6 and E7 proteins are key oncogenes in the development of HPV-associated tumors, and therapeutic vaccines targeting HPV16 E6 and E7 tumor-specific antigens -- such as Vvax001 -- "represent an ...

an arenavirus-based product candidate that targets the highly antigenic HPV16 E6 and E7 proteins and is currently being developed to treat HPV-associated head and neck cancers. HB-200 is in a ...

"Nearly all premalignant cervical lesions and cervical cancers are caused by HPV infection ... cannot replicate and produces the oncogenic E6 and E7 proteins that are expressed exclusively ...