Traditionally, the protein synthesis in mitochondria has been considered primarily ... The excessive cytosolic iron stimulated the overproduction of heme, a major component of hemoglobin important for ...

A team of researchers has uncovered a previously unrecognized role of mitochondrial protein synthesis in the maintenance of intracellular iron distribution. Disruption of this process was found to ...

which result from defective synthesis of one or more hemoglobin chains, have been identified. Notably, sickle cell anemia was the first genetic disease to be examined at the molecular level.