Hepatic stellate cells control liver function and regeneration. ScienceDaily . Retrieved April 5, 2025 from www.sciencedaily.com / releases / 2025 / 03 / 250312124015.htm ...

Phenotypic features of hepatic stellate cell activation during liver injury and resolution. Following liver injury, hepatic stellate cells undergo "activation" which connotes a transition from ...

Until now, doctors knew hepatic stellate cells mainly as drivers of liver fibrosis. The actual functions of this cell type have hardly been studied to date. Researchers from the German Cancer ...

Researchers at the German Cancer Research Center Deutsches Krebsforschungszentrum (DKFZ) and their collaborators have cast new light on the mechanisms by which hepatic stellate cells control liver ...

The ECM components in fibrotic liver are similar regardless of the underlying cause. Activation of hepatic stellate cells is the central event in hepatic fibrosis. These perisinusoidal cells ...

More information: Atsushi Sugimoto et al, Hepatic stellate cells control liver zonation, size and functions via R-spondin 3, Nature (2025). DOI: 10.1038/s41586-025-08677-w ...

New research identifies the liver protein PTPRD as a key regulator of metabolic liver disease. Reduced levels of PTPRD disrupt glucose and lipid metabolism, promote liver fat accumulation, and impair ...

However, chronic liver injury can severely impair this regenerative capacity, leading to liver fibrosis. Hepatic stellate cells (HSCs), the liver's primary mesenchymal cells, play a critical role ...

High levels of ammonia kill liver cells by damaging the mitochondria ... levels of ammonia by causing mitochondrial dysfunction (hepatic mitochondriopathies). In the study, the researchers ...

BioHarvest demonstrated that in human hepatic (liver) cells, the Olive Cell compound mitigated fat accumulation in a liver steatosis model as well as in experimental models of liver fibrosis.