MANY of the natural pyrrolizidine alkaloids isolated from various plants are not only acutely hepatotoxic, but are also able to produce subacute and chronic liver lesions in rats when given in an ...

as cell membrane stabilisers and permeability regulators that prevent hepatotoxic agents from entering hepatocytes; (iii) as promoters of ribosomal RNAsynthesis, stimulating liver regeneration ...

Drug-induced liver injury (DILI) is common because it can be caused by different pharmacological agents from nearly all classes of medications, including hepatotoxic drugs, anesthetics, anticancer ...