Long QT syndrome type 2 (LQTS2) affects the HERG or KCNH2 gene on chromosome number seven. This mutation disrupts the normal operation of the potassium channels that control the heart's rhythm.

Inherited mutations in the hERG channel gene, or drug-induced inhibition of channel function lead to inherited or acquired Long QT syndrome (LQTS) and the development of lethal cardiac arrhthymias. As ...

Inherited mutations in the hERG channel gene, or drug-induced inhibition of channel function lead to inherited or acquired Long QT syndrome (LQTS) and the development of lethal cardiac arrhthymias. As ...

I have general expertise in cardiac ion channel pharmacology and antiarrhythmic drug action, and a particular interest in the hERG potassium channel, which plays an important role in drug-induced ...