Nephronophthisis (NPH) is a recessive cystic kidney disease responsible for 10% to 20% of pediatric end-stage renal disease cases. NPHP1 (nephrocystin 1) is the most frequently implicated among over ...

研究揭示沙眼衣原体（Chlamydia trachomatis）效应蛋白 Tarp 的 N 端可改变宿主 Hippo 信号，影响细胞增殖与生存。 ### 沙眼衣原体（Chlamydia trachomatis，Ct）的威胁与谜团 沙眼衣原体是一种革兰氏阴性、专性细胞内寄生菌，在全球范围内，它是导致感染性失明的主要原因。

Single-cell analysis revealed the molecular triggers that drive stem cells to become cancerous, which may help inform ...

Among these signals, the TGF-β and HIPPO pathways are critical, functioning as tumor suppressors and regulating liver development and regeneration. The review focuses on these pathways' interplay ...

Hippo signalling is a cell signalling pathway that controls organ size. Activation of Hippo results in a series of phosphorylation events that culminate in the phosphorylation and cytoplasmic ...

The expansion of the Salvador (SAV)–Warts (WTS)–Hippo (HPO) pathway continues with three recent papers that extend the list of upstream regulators and identify links to Wnt signalling.

California-based Vivace Therapeutics has announced the closing of a $35 million Series D financing. The proceeds will support ...

Vivace Therapeutics, Inc., a small molecule discovery and development company developing first-in-class cancer therapies targeting the Hippo pathway, today announced the closing of a $35 million ...

Two seemingly disparate signaling pathways -- one that controls organ size in fruit flies and another important for the growth of embryos -- interact in embryonic mouse hearts to restrict cell ...