What is the histone code? Different chemical marks, such as acetylation, methylation, or phosphorylation, are made to numerous residues on the N-terminal tails of histone proteins. Some posit that ...

1 Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA 2 Department of Chemistry, Princeton University, Princeton, NJ 08544, USA Histone post-translational modifications ...

Recent work in The EMBO Journal describes a new hybrid post-translational modification of proteins, composed of a poly-ubiquitin chain that is attached to a target protein via a mono-ADP-ribose (MAR) ...

These observations strongly suggested that two major classes of histone modification might act in opposition to help specify a gene regulatory code for the β-globin gene. That is, transcriptional ...

From these differences in overlap, Oren says the histone codes “appear more absolute” whereas mammalian rules seem “more flexible.” Ultimately, Oren's team found this detour away from ...