Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

New research reveals that bacteria form species and maintain cohesion through frequent DNA exchange within species. This ...

New research shows bacteria form distinct species and maintain cohesion through frequent DNA exchange via homologous recombination.

Molecular Cell. 1999). Whereas nonhomologous repair of DSBs is intact in these cells, homology-directed repair is significantly impaired. Homologous integration of transfected DNA is also reduced.

"When DNA damaged by radiation therapy was repaired by a method called homologous recombination, cancer cells died during the process of reproducing—a process called cell division or mitosis.

In short, while bacteria may not have “sex lives” in the way humans do, their frequent DNA exchanges play a crucial role in keeping their species distinct and thriving. This discovery opens up ...

Published in Cell Reports Medicine, results of a VHIO-led study support the feasibility of using RAD51 testing to complement ...

Luckily, cells have developed a complex set of repair mechanisms to protect vulnerable DNA and fix damage so that the cell’s genomic instruction manual remains intact. Cells use homologous ...

Published in Cell Reports Medicine, results of a VHIO-led study support the feasibility of using RAD51 testing to complement next-generation ...