这些研究发现支持了RAD51测试在调整早期乳腺癌患者疗法策略上的潜力，未来的生物标志物的驱动研究（比如RADIOLA研究）就旨在验证RAD51在晚期乳腺癌中的作用，其结果预计将会在今年晚些时候公布，而研究人员应该考虑利用目前的数据来完善分层因素并改善 ...

TROP2 expression in small bowel adenocarcinoma: A potential target for novel therapeutic strategies. This is an ASCO Meeting Abstract from the 2025 ASCO Gastrointestinal Cancers Symposium. This ...

Analysis of tumor microenvironmental features of primary and synchronous liver metastases from patients with colorectal cancer using a deep learning algorithm. Real-world analysis of the impact of ...

Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

Published in Cell Reports Medicine, results of a VHIO-led study support the feasibility of using RAD51 testing to complement ...

"The GeparOla trial included patients with early HER2-negative breast cancer who had homologous recombination deficiency, HRD. In this post hoc analysis, we evaluated if the RAD51 test could ...

Its safety profile was also found to be tolerable, with no significant safety concerns identified. Both homologous recombination deficiency (HRD)-positive and HRD-negative subjects’ groups benefited ...

Published in Cell Reports Medicine, results of a VHIO-led study support the feasibility of using RAD51 testing to complement next-generation ...

"A key objective of research focused on early-stage breast cancer is to identify biomarkers that can select patients who might benefit from less aggressive treatments than chemotherapy and ...