In the model proposed by Wolffe and colleagues, the winged-helix DNA binding domain of the linker histone binds the nucleosomal DNA ∼65 base pairs away from the dyad of symmetry and places the C ...

so histones bind with DNA very tightly. The basic repeating structural (and functional) unit of chromatin is the nucleosome, which contains eight histone proteins and about 146 base pairs of DNA ...

The DNA is then transfected into human cells that have been engineered to express a fusion protein consisting of a LacO binding domain and a factor called HJURP. The fusion protein binds to the LacO ...

The team detected a histone fold in an uncharacterized B. bacteriovorus’ protein called Bd0055 and wondered if this protein could help orchestrate DNA packaging. By observing that, in the presence of ...

Dopamine, serotonin, and histamine carry messages between neurons. They can also influence circadian gene expression ...

A cell protein previously believed only to provide a scaffolding for DNA has also been shown to directly influence DNA transcription ... the gene they discovered in apples encodes a linker histone.

A cell protein previously believed only to provide a scaffolding for DNA has also ... encodes a linker histone. Unexpectedly, they found that this linker histone binds to the promoter of the ...

These bind to the tightly packaged DNA in order ... We found that Nr5a2 weakens DNA minor groove-histone interaction through direct competition and induces structural changes in core histones.