There are several reasons why this might be, including the capacity of hypoxia to drive genomic instability and alter DNA damage repair pathways. Significantly, current models fail to distinguish ...

With the final step in HIF pathway established, scientists began to explore ways to utilize it. Because the hypoxia response is present across all tissues and cell types, the HIF pathway drives ...

The miR-1 family, which includes miR-1, -133 and -206, among others, has been proven to be a muscle-specific miR family; they have a critical role in myogenesis and ...

By adding the stress of hypoxia during ‘aerobic’ or ‘anaerobic’ interval training, it is believed that IHT would potentiate greater performance improvements compared to similar training at sea level.

Dihydromyricetin (Dih), a naturally occurring flavonoid, has been identified to exert a protective effect against ischemia/reperfusion injury. However, the detailed mechanisms remain unclear. Here we ...

TILs and tumor cells utilize the same metabolic pathways for their growth and function, and co-live in the metabolically harsh tumor-microenvironments characterized by hypoxia and poor nutrition ...