For example, inhibitor of apoptosis proteins (IAPs) are natural inhibitors of caspases. Antisense molecules and small-molecule antagonists of the IAP family members such as XIAP and survivin are ...

Survivin, a homodimeric member of the Inhibitor of Apoptosis Protein (IAP) family, is required for cancer cell survival and overexpressed in almost all solid tumors. The LQZ compound series targets ...