For example, inhibitor of apoptosis proteins (IAPs) are natural inhibitors of caspases. Antisense molecules and small-molecule antagonists of the IAP family members such as XIAP and survivin are ...

Licensed from Debiopharm in 2021 in a $1 billion-plus deal, xevinapant had been leading the field among drugs in the inhibitor of apoptosis proteins (IAP) antagonist class ahead of rival drugs ...

Small molecule inhibitor of survivin dimerization for the treatment of solid tumors. Survivin, a homodimeric member of the Inhibitor of Apoptosis Protein (IAP) family, is required for cancer cell ...