Study identifies potential role of interferon signaling in progressive spinal disease
The type I IFN signaling pathway was found to be activated during the progression of ossification, with IFN-related genes such as OAS2, OAS3, IRF7, MX1, MX2, and STAT1 exhibiting higher expression ...
EurekAlert!5d
RNF167 mediates atypical ubiquitylation and degradation of RLRs via two distinct proteolytic pathways
The precise regulation of the RIG-I-like receptors (RLRs)-mediated type I interferon (IFN-I) activation is crucial in antiviral immunity and maintaining host immune homeostasis in the meantime. Here, ...
Mirage News4d
RNF167 Aids Unusual RLRs Breakdown Through Dual Paths
The precise regulation of the RIG-I-like receptors (RLRs)-mediated type I interferon (IFN-I) activation is crucial in antiviral immunity and ...
EurekAlert!3d
PP2A regulates CD8+ T cell effector functions through AKT signaling pathway: implications for immunotherapy
A groundbreaking study published in Research (2025, DOI: 10.34133/research.0545) has elucidated the molecular mechanisms by which protein phosphatase 2A (PP2A) regulates CD8+ T cell-mediated immune ...
Medscape4d
A New Era for IFN-α in the Treatment of Philadelphia-negative Chronic Myeloproliferative Neoplasms
IFN-α2 (in most centers today pegylated IFN-α2 [Peg-IFN-α2]) induces major or complete molecular remissions in a subset of JAK2V617-positive patients with essential thrombocythemia (ET) and ...
EMBO Press4d
PARP7 as a new target for activating anti-tumor immunity in cancer
PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...