signaling in the pathogenesis of OPLL, particularly the type I IFN pathway, which is known to play a role in innate immune responses and bone formation. A single-cell transcriptome profiling study ...

These heart cells rupture and leak DNA, which sparks a damaging immune response. This breakthrough challenges long-held ...

Inflammation and mitochondrial function as mechanisms in accelerated aging (AA) across substance use disorders (SUDs). This ...

To examine how changes in these pathways affect ISCs, the researchers treated intestinal organoids with IFN-γ and iMEK (an inhibitor of MEK/ERK MAPK signaling). Notably, iMEK induced a quiescent ...

This study presents a valuable finding that KDM5 inhibition activates the interferon response and antigen presentation genes in breast cancer cells through R-loops. The evidence supporting the claims ...

New research from UTHealth Houston reveals that substance use disorders accelerate biological aging in the brain through ...