撰文丨王聪编辑丨王多鱼排版丨水成文干扰素基因刺激因子（STING）通路在启动针对病原体和肿瘤的免疫反应中发挥着关键作用。STING 信号的激活对于多种癌症疗法的抗肿瘤效果至关重要，STING ...

*仅供医学专业人士阅读参考对抗肿瘤免疫应答至关重要的STING通路，最近在奇点糕这儿出镜率可真不低，估计在围观癌细胞和免疫细胞围绕STING展开攻防的同时，不少读者也会想到同一件事：与其绕弯子从其它调控机制入手，是不是早该有药物可以直接激活STING通路了呢？还别说，从2018年起就有STING激动剂报告初步人体临床研究结 ...

为探究 TBK1 如何转运至 TGN 激活 STING-IFN-I 信号通路，研究人员发现 TGN 拴系因子不可或缺，这对理解衰老相关免疫变化意义重大。 在人体的免疫系统中，存在着一套精密的防御机制，其中 cGAS-STING 通路（环鸟苷酸 - 腺苷酸合成酶 - 干扰素基因刺激蛋白通路 ...

PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...

while overexpression ramped up IRF3 and IFN-β production through STING. The level of IFN-β induction by cGAS was similar to that of MAVS when compared to other putative DNA sensors. Because cGAS was ...

A novel strategy using lipid nanoparticles to reprogram liver immunity shows promise in generating antitumor responses ...