▎药明康德内容团队编辑（来源：复旦大学）近日，复旦大学附属华山医院刘杰教授、骆菲菲研究员团队在《肿瘤细胞》（Cancer Cell）发表题为“Targeting tumor monocyte-intrinsic PD-L1 by rewiring ...

撰文丨王聪编辑丨王多鱼排版丨水成文干扰素基因刺激因子（STING）通路在启动针对病原体和肿瘤的免疫反应中发挥着关键作用。STING 信号的激活对于多种癌症疗法的抗肿瘤效果至关重要，STING 激动剂在小鼠模型中治疗不同癌症方面展现出了令人瞩目的潜力。然而，STING ...

为探究 TBK1 如何转运至 TGN 激活 STING-IFN-I 信号通路，研究人员发现 TGN 拴系因子不可或缺，这对理解衰老相关免疫变化意义重大。 在人体的免疫系统中，存在着一套精密的防御机制，其中 cGAS-STING 通路（环鸟苷酸 - 腺苷酸合成酶 - 干扰素基因刺激蛋白通路 ...

PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...

A novel strategy using lipid nanoparticles to reprogram liver immunity shows promise in generating antitumor responses ...

while overexpression ramped up IRF3 and IFN-β production through STING. The level of IFN-β induction by cGAS was similar to that of MAVS when compared to other putative DNA sensors. Because cGAS was ...