Cerulein or alcohol decreases pancreatic TFEB, resulting in impaired lysosomal biogenesis and insufficient autophagy. Autophagy may selectively remove damaged mitochondria (mitophagy), abnormal ER ...

A new research paper was published in Aging (Aging-US) on March 18, 2025, in Volume 17, Issue 3, titled “Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not ...

Boosting the recycling process known as autophagy — impaired in the brain during prolonged stress — has the potential to restore normal neuronal activity and treat depression. Yang and ...

Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down waste materials, damaged ...

" [...] our work suggests that increased mtROS or decreased Atg7-dependent autophagy in osteoblastic cells, as well as reduced osteocyte dendrite number – common features of aged bone – do not ...

In Parkinson’s disease (PD), damaged mitochondria build up in the dopaminergic system of the substantia nigra, partly due to impaired mitochondrial autophagy (mitophagy) and autophagosome accumulation ...

Hence, this is one of the most important processes in our body. Impaired autophagy is linked to cardiovascular diseases, neurodegenerative diseases like Alzheimer's disease and Parkinson's disease ...

However, when the researchers examined younger mice genetically modified to have either high oxidative stress or impaired autophagy, as seen in aging, their bones still responded normally to ...