The drugs are organized into six different classes ... Without the means to enter a cell, HIV cannot replicate. Integrase ...

Historically, most people started HIV treatment with two drugs from the NRTI class combined with either one NNRTI, one protease inhibitor or one integrase inhibitor – hence, ‘triple therapy’.

Dolutegravir is an HIV integrase strand transfer inhibitor (INSTI ... enzymes and therefore is associated with few drug interactions other than metformin and dofetilide. Dolutegravir should ...

INSTIs belong to a category of drugs known as integrase inhibitors. INSTIs are well-established drugs. Doctors often use ritonavir (Norvir) as a booster drug for protease inhibitors. Due to their ...

Dolutegravir (Tivicay) belongs to the class of antiretroviral drugs known as integrase inhibitors. The drug works against HIV's integrase protein, blocking its ability to integrate its genetic code ...

New drugs have transformed the treatment of ... project [which has now resulted in the approval of the first HIV integrase inhibitor, raltegravir] and can see once again how a compound with ...

a convenient combination that will compete with Gilead's nearly-approved three-drug regimen. Juluca combines GSK’s already approved integrase inhibitor Tivicay (dolutegravir) with Janssen’s ...

The combination of these drugs with nucleoside reverse transcriptase inhibitors began the era ... HIV cell fusion and HIV integrase (Supplementary information S1 (table); available online).