Nature6 年
Cdc42 has a key role in modulating osteoclast formation and function
A new study in mice shows how the small GTPase Cdc42 influences bone modeling and remodeling—it modulates both the formation and function of osteoclasts, and is involved in the downstream ...
生物通7 天
Activity-dependent regulation of Cdc42 by Ephexin5 drives synapse growth and stabilization ...
为解决 Ephexin5（E5）在神经元可塑性调节中作用机制不明的问题，研究人员开展了 E5 对 Cdc42 和 RhoA 调控作用及相关机制的研究。结果表明 E5 可激活 Cdc42 和 RhoA，且其底物选择性受神经元活动和酪氨酸磷酸化调控，该研究为相关疾病治疗提供新思路。 大脑中的 ...