Microglia, the brain's immune cells, usually serve as diligent guardians. They eliminate intruders such as microbes and clear ...

Biologics targeting interleukin-12, -23, and -17 were associated with a lower rate of serious infections among older adults ...

share their discovery that a cytokine called interleukin-12 (IL-12) acts like a switch to direct which antibody response B cells will generate. Both B-cell responses are biologically important ...

When interleukin-12 is added to the cell culture, it leads to a significant reduction in nerve fibers (pink) and oligodendrocytes, and thus to a decline in myelin (white).

KaliVir Immunotherapeutics, Inc., a clinical-stage biotechnology company developing cutting-edge, multi-mechanistic oncolytic immunotherapy programs, today announced the upcoming presentation of a ...

Ustekinumab is a human interleukin-12 and -23 antagonist indicated for multiple chronic inflammatory diseases. A biosimilar is a biological product that is approved based on data demonstrating ...

Researchers have detailed the precise mechanism through which the inflammatory signaling molecule IL-12 contributes to Alzheimer's disease. Microglia, the brain's immune cells, usually serve as ...

and Interleukin-12 (IL-12) INDUKINE molecules, respectively, for the treatment of solid tumors. Werewolf is advancing WTX-124 in multiple tumor types as a single agent and in combination with an ...