Here we discuss chemical tools and detection methods that could be effectively combined to make significant progress in understanding the dynamics of intracellular signaling pathways ...

In addition, the association of CD3 with the TCR–peptide–MHC complex transmits the activation signal to intracellular signalling molecules to initiate a signalling cascade in the T cell.

Postsynaptic A1 and D1 receptors exert opposing influences one another including allosteric receptor-receptor interactions and opposing intracellular signaling cascades. It remains unclear how these ...

Lipid metabolism has emerged as a central player in the progression and therapy resistance of breast cancer, particularly the aggressive subtype known as triple-negative breast cancer (TNBC).

The findings highlight the significance of frequency-selective cellular responses in developmental biology, providing ...

Proteins are fundamental biomolecules that perform a broad range of vital functions within the human body. They serve as an essential structural and functional component of cells, tissues and organs ...

Intracellular checkpoint molecules ... IL-15 activates CIS, a negative regulator of IL-15 signaling in NK cells, and its absence increases NK cell sensitivity to IL-15, proliferation, survival ...