In this type of diabetes, the immune system specifically destroys insulin-secreting beta cells in the pancreatic islets — the body's own immune system attacks its own cells (a form of autoimmune ...

Three people with type 1 diabetes who received Vertex Pharma’s islet cell therapy VX-880 have been ... reduction of haemoglobin A1c levels – a marker of blood glucose control – to 7% or ...

Delineating the role of the miR-146b/Btg2 axis in beta cell decline during the progression of obesity to T2DM.

PDX-1 is a critically important transcription factor for the insulin promoter, is absent in glucotoxic islets, and, when transfected into glucotoxic ß-cells ... of elevated markers of oxidative ...

Current treatments for T1D, including islet cell transplants ... For Tregs, this means designing CARs that bind only to unique markers on transplanted tissues, ensuring precise immune protection.