Among these, RAF1 S257, S259, G361, and R391 mutations are oncogenic or likely oncogenic mutations that confer increased kinase activity. 35 Conversely, among 66 class 3 MAP2K1-mutated tumors, no RAF1 ...

Erlotinib is a quinazoline derivative that selectively and reversibly inhibits the tyrosine kinase activity of the EGFR. Here, we review the mechanism(s) of action of erlotinib, as well as the ...

Researchers from the Nagoya University Graduate School of Medicine identified an enzyme, alpha-kinase 2 (ALPK2) that is ...