Cyclin-dependent kinases (CDKs ... lack at least one of the conserved catalytic residues 2 and may not have kinase activity. Kinase activity has not been detected for several CDK-related proteins ...

blocked the activity of the cyclin D–Cdk4/6 complex before and after the cell cycle was arrested with hydroxyurea. Centrioles did not duplicate when this kinase complex was inhibited before the ...

Every organism—from the smallest yeast to complex human beings ... "Basically, the pocket of cyclin B functions like a Velcro fastener connecting the kinase and the substrate.

Cyclin D1–CDK4/6 phosphorylates GTSE1 in cancer cells, preventing its degradation and sustaining high levels across the cell cycle, which enhances proliferation and correlates with poor prognosis.

An enzyme called cyclin-dependent kinase 2 (CDK2) regulates the cell ... respond to CDK2 inhibitors in a complex process that can hamper the ability of tumor cells to divide.