EGFR kinase domain mutations hyperactivate the kinase and confer a dependence on the mutated kinase for the survival of the NSCLC tumour cells. The treatment of sensitive cells with targeted ...

During a Case-Based Roundtable® event, Catherine Coombs, MD, discussed the BRUIN trial and recent NCCN updates on chronic ...

It was found that a phospho-dead mutation at Y163 abolished the inhibitory ... In a search for the kinase responsible for PDK1 Y163 phosphorylation, TIE1 was identified as a potential candidate.