例如，虽然 LRRK2 的 G2019S 突变会增强激酶活性，但转基因 G2019S 过表达小鼠和 G2019S 敲入（knock-in，KI）小鼠并不会自发形成典型的 LB 或 LB 样 α-syn 包涵体。同时，体内研究也未能明确证明 G2019S KI 小鼠存在主要的自噬溶酶体途径（autophagy-lysosomal pathway，ALP ...

The researchers found, as expected from prior studies that LRRK2 is associated with IBD-PD and discovered new associations as well. Their ability to identify new genes involved in autophagy and ...

Their findings point to mutations in the LRRK2 gene as a common element linking ... inflammation, and autophagy, the body's cellular recycling system, that are involved in both conditions.

(Phospho)proteomic analyses of cellular models of LRRK2 and PINK1 should aid the ... cell to remove aggregating protein may involve both autophagy and the UPS. Released aggregated α-synuclein ...