The researchers found, as expected from prior studies that LRRK2 is associated with IBD-PD and discovered new associations as well. Their ability to identify new genes involved in autophagy and ...

(Phospho)proteomic analyses of cellular models of LRRK2 and PINK1 should aid the ... cell to remove aggregating protein may involve both autophagy and the UPS. Released aggregated α-synuclein ...

Their findings point to mutations in the LRRK2 gene as a common element linking ... inflammation, and autophagy, the body's cellular recycling system, that are involved in both conditions.