现有研究表明，自噬（autophagy）激活是肿瘤细胞逃避顺铂毒性的重要机制，但溶酶体膜稳定性如何调控这一过程仍属未知。山东第一医科大学附属肿瘤医院的研究团队在《Cellular Signalling》发表的研究，首次阐明溶酶体跨膜蛋白LAPTM5通过分子伴侣机制稳定LAMP1蛋白 ...

本研究针对水产养殖中高脂饲料(HFD)诱导的非酒精性脂肪肝病(NAFLD)问题，通过UPLC-MS/MS技术鉴定垂盆草(SSB)活性成分齐墩果酸(OA ...

In 2000, it was suggested to me that “Autophagy will be the wave of the future; it will become the new apoptosis.” Few people would have agreed at the time, but this statement turned out to be ...

"This paper focuses on the theme of how autophagy-dependent secretion regulates autophagy itself," said Li Qilong, first author of the review. "We systematically explore the homeostatic ...

Domain architecture and orientation of LAMP1 and LAMP2 in the lysosome lumenal membrane(left). Schematic β-prism shapes and the structures of the C-domain of ...