The CD34+CD38− cells, isolated from acute myeloid leukemia (AML), were shown to be enriched leukemic stem cells (LSC). We isolated the CD34+CD38− cell fraction from AML and compared their gene ...

Despite their initial efficient response to induction chemotherapy, relapse remains frequent in patients with T-cell acute lymphoblastic leukemia (T-ALL), an aggressive malignancy of immature T ...

Changes in Blood Cell Production Over the Lifetime Could Impact Leukemia Outcomes Dec. 5, 2024 — The first comprehensive map of the dramatic changes that take place in the blood system over the ...

Hu-Mikβ1 was evaluated in a Phase I clinical trial in patients with T-cell large granular lymphocyte leukemia. Hu-Mikβ1 was shown to be safe in Phase I trials; however, no therapeutic efficacy ...

In T cell cancers such as T cell lymphoblastic leukemia (TLL), this challenge arises from fratricide, CAR T cell self-destruction. 1–3 CAR T cells often share the same receptors as malignant T cells, ...

From the deaths of John Sykes and former Planned Parenthood President Cecile Richards to an update from Mike Peters, here’s ...

Her results were published October 2024 in the journal Leukemia. Cells were sourced from samples from patients with leukemia, laboratory-generated models of human leukemia and established human ...

Introducing individual mutations to mtDNA is challenging due to the large number of mitochondria within each cell. Instead, the researchers used a leukemia mouse model with a defective genetic ...

Patients with acute myeloid leukemia who relapse after stem cell transplantation have just a small chance of survival: doctors can give them additional donor T cells to fight the cancer, but only ...