Cite this: Targeting Ligand-gated Ion Channels in Neurology and Psychiatry: Is Pharmacological Promiscuity an Obstacle or an Opportunity? - Medscape - Mar 02, 2010.

Thus far, one antibody (BIL010t; Biosceptre) that targets a nonfunctional form of the ligand-gated ion channel P2X purinoceptor 7 has reached clinical trials for the treatment of basal cell carcinoma.

Their findings are published in Science Advances. Cys-loop receptors are ligand-gated ion channels with two domains connected by a short linker. The top domain is located extracellularly ...