Similar approaches will likely be applicable to many other members of the various GPCR subfamilies. Structures of the receptors in their multiple active conformations, stabilized with ligands ...

G protein-coupled receptors (GPCRs) play a central role in the pathogenesis and development of osteoporosis, a serious bone metabolism-related disease.

GPCRs are the targets for around one third of ... perhaps they don’t have ligands and are controlled just by their expression or turnover in the cell.” One thing is clear: there’s still ...

G protein coupled receptors (GPCRs) are the most abundant receptor family encoded by the human genome. They are involved in all aspects of mammalian cellular life, and are extraordinarily diverse both ...

Learn how Free Energy Perturbation was used to accurately predict binding affinities for 30 ligands that bind to the lipid and GPCR interface in P2Y1.

GPCRs are versatile cell-surface receptors that ... which is activated by bioorthogonal drugs and insensitive to native ligands. Bioorthogonal drugs can perform chemical reactions within living ...

The study specifically examines two types of GPCRs expressed on astrocytes: dopamine D1 receptors (D1R) and metabotropic ...

We also vigorously performed the “deorphanization” of orphan GPCRs during the project, and identified novel ligands for GPR103 and GPR7/8. We showed that the ligand of GPR103 has an essential function ...