In human cells, lipid droplets (LDs) predominantly contain either cholesteryl esters or triacylglycerols. This article ...

Researchers say they are exploring therapeutic options to block fatty acid accumulation and immunosuppressive signals between cancer cells and neutrophils.

Once thought to be little more than blobs of fat inside eukaryotic cells, lipid droplets may in fact provide a first line of defence against invading pathogens, according to evidence published today ...

Lipid accumulation in tumor cells and nearby immune cells promotes immune suppression and therapy resistance in ...

in particular the mechanisms and physiology of neutral lipid synthesis and storage in lipid droplets. More broadly the lab studies the mechanisms how cells regulate the abundance of lipids, how they ...

However, some initially responsive tumors still develop recurrences. Researchers studied mouse models and found that TNBC cells that survived treatment accumulated lipid droplets containing Omega-6 ...

Tumor-derived arachidonic acid reprograms neutrophils to promote immune suppression and therapy resistance in triple-negative breast cancer - ...