近年来，随着蛋白质组学技术的飞速发展，科研人员逐渐揭开了蛋白质翻译后修饰（PTM）在疾病发生发展中的重要作用。其中棕榈酰化（S-palmitoylation）作为一种重要的脂质修饰方式，逐渐成为研究热点。棕榈酰化通过在蛋白质的半胱氨酸残基上添加棕榈酸（PA），调控蛋白质的稳定性、定位和功能，进而影响多种生理和病理过程。

在本次研究中，研究者们首先挑选了成瘤后微环境内相对富集中性粒细胞的TNBC细胞系进行建模，发现PD-1抑制剂和紫杉醇联合治疗仅能完全清除2208L细胞系、且能够建立长期免疫记忆，联合治疗对其它3种TNBC细胞系均疗效有限，但停止联合治疗后仍有少数小鼠 ...

Scientists have discovered a new protein pathway involved in neurodegeneration by studying “mini-brain” organoids made from ...

细胞器是真核细胞的标志性特征，但关于细胞器的生物发生仍有许多未知。脂质滴（lipid droplets）和过氧化物酶体（peroxisomes）在脂肪的储存和分解代谢中发挥相反作用，它们从内质网（endoplasmic reticulum，ER）的一个神秘区域形成。研究人员利用活细胞荧光显微镜 ...

Researchers say they are exploring therapeutic options to block fatty acid accumulation and immunosuppressive signals between cancer cells and neutrophils.

Lipid accumulation in tumor cells and nearby immune cells promotes immune suppression and therapy resistance in ...

However, some initially responsive tumors still develop recurrences. Researchers studied mouse models and found that TNBC ...

An Osaka Metropolitan University-led study demonstrated that Cdc42 (cell division cycle 42) plays a crucial role in the formation and maintenance of the morphological characteristics of quiescent ...

Once thought to be little more than blobs of fat inside eukaryotic cells, lipid droplets may in fact provide a first line of defence against invading pathogens, according to evidence published today ...