In this 6-week, double-blind trial, 585 patients were randomized to losartan/ hydrochlorothiazide or losartan as monotherapy and titrated as needed at 2-week intervals to reach goal blood pressure ...

The primary end point was the proportion of patients achieving goal mean trough SiDBP (<90 mm Hg) after 4 weeks of therapy with either losartan 50 mg/HCTZ 12.5 mg or a losartan monotherapy regimen ...