Cargo proteins that are destined for lysosomal degradation are first incorporated into intraluminal vesicles (ILVs), which form by the invagination of endosomes; this process turns endosomes into ...

These vesicles were shown to contain fragments of mitochondria and endoplasmic reticulum as well as lysosomal enzymes. In a conference on lysosomes in 1963, Christian de Duve appropriately coined ...

In the study titled "Lysophagy protects against propagation of α-synuclein aggregation through ruptured lysosomal vesicles," published in Proceedings of the National Academy of Sciences ...

This information is of particular importance to patients with Danon’s disease, who have mutations in a lysosomal protein that causes cardiomyopathy. We discovered that fibroblasts and cardiac myocytes ...

In endocytosis, the cell takes in materials from outside by wrapping them within vesicles, which carry them ... causing diseases known as lysosomal storage diseases (LSD) in humans.